MICOMWeb: a website for microbial community metabolic modeling of the human gut

SummaryMICOMWeb is a user-friendly website for easy microbial community metabolic modeling of the human gut. This website tackles three constraints when generating in silico metagenome-scale metabolic models: (i) the prior Python user knowledge for metabolic modeling using flux balance analysis with MICOM Python package, (ii) predefined and user-defined diets to generate ad hoc metabolic models, and (iii) the high- throughput computational infrastructure required to obtain the simulated growth and metabolic exchange fluxes, using real abundance from metagenomic shotgun or 16S amplicon sequencing; we present MICOMWebs features to easily run in silico experiments as a functional hypothesis generator for experimental validation on previously published data. Availability and ImplementationMICOMWeb is freely accessible for academic purposes at https://micomweb.c3.unam.mx.