Author

S. El Aidy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:human· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Assay:metabolomics· 3 Assay:metagenomics· 3

Frequent Co-Authors

J. Jansma· 3 shared M. Schwalbe· 3 shared S. K. Mahata· 3 shared A. C. Chatziioannou· 2 shared A. Danewalia· 2 shared B. Dalile· 2 shared H. Permentier· 2 shared K. Verbeke· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

J. Jansma

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Metabolic network construction reveals probiotic-specific alterations in the metabolic activity of a synthetic small intestinal community

J. Jansma, A. C. Chatziioannou, K. Castricum, S. van Hemert, S. El Aidy

This study constructs a synthetic small intestinal microbiota community to investigate how probiotics alter metabolic activity and colonization resistance in a probiotic-specific manner.

bioRxiv · Mar 29, 2023Microbiology

Probiotics supplementation to adult human small intestinal stoma microbiota causes dynamic increase in the community resistance to perturbations and nutrient utilization

J. Jansma, N. U. Thome, M. Schwalbe, A. C. Chatziioannou, S. S. Elsayed, G. van Wezel, P. van den Abbeele, S. van Hemert, S. El Aidy

This study shows how probiotic supplementation to adult human small intestinal stoma microbiota alters nutrient utilization and resistance to perturbations through changes in metabolite production.

bioRxiv · Jan 29, 2023 · PreprintMicrobiology

Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts

P. Gonzalez-Davila, M. Schwalbe, A. Danewalia, R. Wardenaar, B. Dalile, K. Verbeke, S. K. Mahata, S. El Aidy

This study shows that gut microbiota transplantation from CST-KO mice to wild-type mice induces colonic fibrosis and tight junction impairment, suggesting a causal role for microbiota in intestinal dyshomeostasis linked to catestatin deficiency.

bioRxiv · Feb 24, 2022Microbiology

Catestatin selects for the colonization of antimicrobial-resistant gut bacterial communities

P. Gonzalez-Davila, M. Schwalbe, A. Danewalia, B. Dalile, K. Verbeke, S. K. Mahata, S. El Aidy

This study shows that catestatin (CST) alters gut microbiota composition and promotes antimicrobial resistance in CST-KO mice, with implications for inflammatory bowel disease.

bioRxiv · Oct 11, 2021Microbiology

Parkinson' disease medication alters rat small intestinal motility and microbiota composition

S. P. van Kessel, A. Bullock, G. van Dijk, S. El Aidy

This study shows that Parkinson's disease medications reduce small intestinal motility and alter microbiota composition in rats, mirroring human PD microbiota changes.

bioRxiv · Jul 19, 2021Microbiology

Understanding the host-microbe interactions using metabolic modeling

S. El Aidy, J. Jansma

This paper reviews how flux balance analysis can be used to study host-microbe interactions in the gut through in silico simulations of metabolic networks.

Microbiome · Jan 20, 2021Peer-reviewedMicrobiology

Loss of C3aR induces immune infiltration and inflammatory microbiota in a novel spontaneous model of colon cancer

C. Krieg, L. M. Weber, B. Fosso, G. Hardiman, E. Mileti, S. El Aidy, M. Marzano, M. D. Robinson, S. Guglietta

This study shows that loss of C3aR in a mouse model of colon cancer leads to immune infiltration and inflammatory microbiota changes.

bioRxiv · Jan 18, 2021 · PreprintImmunology

Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

E. M. Muntjewerff, K. Tang, L. Lutter, G. Christoffersson, M. J. T. Nicolasen, H. Gao, G. D. Katkar, S. Das, M. t. Beest, W. Ying, P. Ghosh, S. El Aidy, B. Oldenburg, G. van den Bogaart, S. K. Mahata

This study shows that Chromogranin A regulates gut permeability through the opposing actions of its proteolytic peptides CST and PST.

bioRxiv · Sep 19, 2020Physiology

pH-dependent spontaneous hydrolysis rather than gut bacterial metabolism reduces levels of the ADHD treatment, Methylphenidate

J. Aresti, W. Maho, R. R. Pereira, H. Permentier, S. El Aidy

This study shows that pH-dependent spontaneous hydrolysis, not gut bacterial metabolism, reduces methylphenidate levels, affecting its bioavailability.

bioRxiv · Jul 6, 2020 · PreprintMicrobiology

Gut bacterial deamination of residual levodopa medication for Parkinson's disease

S. P. van Kessel, H. R. de Jong, S. L. Winkel, S. S. van Leeuwen, S. A. Nelemans, H. Permentier, A. Keshavarzian, S. El Aidy

This study shows that gut bacteria deaminate levodopa, a Parkinson's disease medication, and identifies the enzyme responsible, with implications for drug effectiveness and side effects.

bioRxiv · Feb 13, 2020Microbiology