Indra Roux

This study shows that the antidepressant duloxetine disrupts RNA-protein interactions in both human and bacterial cells, revealing a new mechanism of drug action.

CarveMe-GutMicrobes reconstructs genome-scale metabolic models for gut microbes from genomic data, showing high accuracy in predicting gene essentiality and metabolite secretion.

This study investigates interactions between low-calorie sweeteners and xenobiotics on gut bacteria, finding synergistic effects that alter bacterial growth and host cell responses.

This study investigates the off-target antibacterial effects of 1076 industrial and agricultural chemicals on 22 human gut bacteria, revealing 588 previously unreported interactions.

The paper develops tools for transposon mutagenesis in Bacteroidales to identify essential genes and functional elements across three gut bacteria.

This study shows human gut bacteria can accumulate PFAS, with some species like Bacteroides uniformis accumulating them to high concentrations, and identifies mechanisms involving transmembrane transport and efflux pumps.

The paper develops improved AMA1-based plasmids for more consistent and stronger gene expression in filamentous fungi, showing increased reporter expression, CRISPRa efficiency, and metabolite production.

The paper develops a system for targeted chromosomal integration of biosynthetic gene clusters in Aspergillus nidulans using Cre/lox-mediated recombination, demonstrating efficient integration and expression of a 21 kb DNA fragment.

A dLbCas12a-VPR CRISPR activation system works in Aspergillus nidulans, boosting microperfuranone output from the native micA gene and revealing dehydromicroperfuranone as the mic cluster product.