The effect of trans-cinnamic acid isolated from the root cultures of the Baikal skullcap (Scutellaria baicalensis) on the life expectancy and survival of Caenorhabditis elegans

Abstract

Oxidative stress is an increase in reactive oxygen species, which are signaling molecules of various pathologies in the body of living beings. Baikal skullcap (Scutellaria baicalensis) is a valuable source of biologically active substances with various pharmacological activity. The aim of the study is to study the effect of trans-cinnamic acid isolated from root cultures of Scutellaria baicalensis on the lifespan of a model organism of C. elegans, as well as its survival under conditions of oxidative and thermal stress. It was shown that trans-cinnamic acid increased the lifespan of nematodes, while the best concentration of phytomaterials was 50 microns. In addition, all tested concentrations (10-200) had a positive effect on nematodes under oxidative stress caused by paraquat. No positive effect of trans-cinnamic acid was detected during thermal exposure. In general, the results show the antioxidant potential of trans-cinnamic acid from plant material under oxidative stress, as well as the positive effect of the substance on the lifespan of C. elegans.