P. C. Phillips

The Egg-Counter: A novel microfluidic platform for characterization of Caenorhabditis elegans egg-laying

The paper introduces a microfluidic platform for studying C. elegans egg-laying, showing higher throughput and temporal resolution compared to traditional methods.

Transcriptomic sexual conflict at two evolutionary timescales revealed by experimental evolution in Caenorhabditis elegans

This study uses experimental evolution in C. elegans to show sex-specific gene expression changes driven by sexual selection, revealing transcriptomic sexual conflict over short evolutionary timescales.

Heritable epigenetic variation facilitates long-term maintenance of epigenetic and genetic variation

This study extends a population-genetic model to include epigenetic variation through epimutation, showing how epialleles can be maintained in equilibrium and influence genetic variation.

Genetic diversity landscapes in outcrossing and selfing Caenorhabditis nematodes

This study compares genetic diversity and recombination patterns between outcrossing and selfing Caenorhabditis nematodes, finding similar genomic patterns but differing in scale and effective population size history.

The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

This study evaluates how compound interventions and genetic background affect healthspan and lifespan in C. elegans under stress conditions.

Alignment of genetic differentiation across trophic levels in a fig community

The paper examines genetic diversity patterns in the nematode C. inopinata across three Okinawan islands, finding it more diverse than C. elegans and showing genetic patterns aligned with its fig wasp vector.

Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain specific lifespan and health effects in Caenorhabditis nematodes

This study evaluates the lifespan and health effects of five compounds in Caenorhabditis nematodes, finding species- and strain-specific responses, assay-dependent outcomes, and uncoupling of lifespan and health effects.

High-throughput imaging of Caenorhabditis elegans aging using collective activity monitoring

The paper introduces WormCamp, a high-throughput system for aging research in C. elegans, showing it can estimate lifespan and healthspan through collective activity monitoring.

Post-Insemination Selection Dominates Pre-Insemination Selection in Driving Rapid Evolution of Male Competitive Ability

This study shows post-insemination selection is more effective than pre-insemination selection in driving rapid evolution of male reproductive success in C. elegans.

Opposing directions of stage-specific body length change in a close relative of C. elegans

This study compares body size changes across developmental stages in C. inopinata and its relatives, finding opposing trends in dauer larva and adult size due to ecological divergence.

Evaluating Human Autosomal Loci for Sexually Antagonistic Viability Selection in Two Large Biobanks

The paper evaluates evidence for sexually antagonistic viability selection on autosomal loci in humans using two large biobanks but finds no significant replication of associations, suggesting limited ongoing selection on single locus variation.

A naturally segregating polymorphism balancing semelparous reproduction versus reproductive diapause revealed via microfluidic assessment of starvation stress in Caenorhabditis elegans.

The paper identifies genetic loci influencing starvation resistance in C. elegans using a microfluidic device and mapping panel, revealing natural variation in reproductive strategies under food deprivation.

Slow recovery from inbreeding depression generated by the complex genetic architecture of segregating deleterious mutations

This study investigates recovery from inbreeding depression in C. remanei, finding limited fitness recovery despite strong selection, due to the fixation of many segregating deleterious mutations.

Experimental evolution of independent genetic pathways for resistance to Pseudomonas aeruginosa pathogenicity within the nematode Caenorhabditis remanei

This study shows that nematodes evolve independent genetic pathways to resist two distinct virulence modes of Pseudomonas aeruginosa.

An open source microfluidic sorter for Caenorhabditis nematodes

The paper describes an open-source microfluidic sorter for Caenorhabditis elegans that can sort individuals based on characteristics like fluorescence, with high repeatability and without affecting offspring production.

Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions

The paper compares manual and automated lifespan assays in Caenorhabditis strains, finding that automated methods reproduce results but show assay-specific effects of chemical interventions.

Limits to Genomic Divergence Under Sexually Antagonistic Selection

This study shows that strong sexually antagonistic selection is needed for measurable sex-specific allelic divergence, and that small samples can falsely inflate male-female genetic differentiation.

Complex pleiotropic genetic architecture of evolved heat stress and oxidative stress resistance in the nematode Caenorhabditis remanei

This study investigates the genetic architecture of heat and oxidative stress resistance in C. remanei, finding polygenic and largely independent genetic bases for these traits.

The Stress-Chip: A microfluidic platform for stress analysis in Caenorhabditis elegans

The paper introduces a microfluidic platform for controlled stress analysis in C. elegans, enabling environmental control and behavioral studies under various stress conditions.

Proteomic and Evolutionary Analyses of Sperm Activation Identify Uncharacterized Genes in Caenorhabditis Nematodes

The paper identifies two novel nematode-specific gene families in Caenorhabditis species and shows they are conserved within the clade but do not affect male fertility when knocked out.

Two levels of host-specificity in a fig-associated Caenorhabditis

This paper describes the natural history of C. sp. 34, a Caenorhabditis species associated with Ficus septica figs and pollinating Ceratosolen wasps, revealing its host-specificity and life cycle patterns.

Environmental and evolutionary drivers of the modular gene regulatory network underlying phenotypic plasticity for stress resistance in the nematode Caenorhabditis remanei

The paper compares transcriptional responses to heat stress in four Caenorhabditis remanei populations, identifying plastic and evolutionary modules in gene regulatory networks.

Quantifying male and female pheromone-based mate choice in Caenorhabditis nematodes using a novel microfluidic technique

The paper introduces a microfluidic technique to study pheromone-based mate choice in nematodes and finds that attraction strength depends on male receptivity and female signal production, with females preferring virgin males.