UVB radiation suppresses Dicer expression through β-catenin

Zackie Aktary; Valérie Petit; Irina Berlin; Jérémy H. Raymond; Frédérique Berger; Nisamanee Charoenchon; Évelyne Sage; Juliette U. Bertrand; Lionel Larue

doi:10.1242/jcs.261978

Molecular BiologyJournal of Cell ScienceOct 23, 2024

Peer-reviewed journal article

UVB radiation suppresses Dicer expression through β-catenin

Zackie Aktary iD, Valérie Petit iD, Irina Berlin iD, Jérémy H. Raymond iD, Frédérique Berger iD, Nisamanee Charoenchon iD, Évelyne Sage iD, Juliette U. Bertrand iD, Lionel Larue iD

Abstract

Ultraviolet (UV) rays prompt a natural response in epidermal cells, particularly within melanocytes. The changes in gene expression and related signaling pathways in melanocytes following exposure to UVR are still not entirely understood. Our findings reveal that UVB irradiation suppresses the expression of Dicer. This repression is intricately linked to the activation of the PI3K, RSK, and WNT/{beta}-catenin signaling pathways and is directly associated with transcriptional repression by {beta}-catenin. Notably, we have identified specific binding sites for the LEF/{beta}-catenin complex in the Dicer promoter. Collectively, these results emphasize the significance of the UV-induced pathway involving LEF/{beta}-catenin, which impacts Dicer expression. This pathway holds potential importance in governing melanocyte physiology.

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