Lionel Larue

This study shows BRN2 is essential for preserving melanocyte lineage integrity after ionizing radiation, but not for normal maintenance.

This study shows E4F1 regulates melanogenesis in mice by controlling protein translation and MITF expression through the ISR pathway.

This study identifies BRN2 as a regulator of melanocyte stem cell resilience under genotoxic stress, showing its role in preventing irradiation-induced hair greying.

This study identifies PSMD14 as a key driver of melanoma survival and resistance to MAPK inhibitors by deubiquitinating histone H2A, altering chromatin state and gene expression.

This study shows melanoblasts use atypical E-cadherin attachments to migrate through epithelial layers without disrupting the barrier.

This study shows UVB radiation reduces Dicer expression via activation of the WNT/β-catenin pathway and direct transcriptional repression.

The paper identifies a novel regulatory mechanism of MITF through SUMOylation and phosphorylation interactions, revealing how mutations affect melanoma predisposition in a mouse model.

The paper shows that activating β-catenin in Schwann-cell precursors during a specific developmental window promotes melanocyte specification over Schwann cell fate.

This study identifies inherited PPP2R3B duplications as a melanoma predisposing factor, revealing a C21orf91-driven proliferative phenotype in melanocytes.