V. Kansal

Orthotopic injection of an established syngeneic mouse oral cancer cell line (MOC1) induces a robust draining lymph node response

This study shows that injecting MOC1 cells orthotopically in the buccal mucosa of mice leads to tumor growth, lymph node enlargement, and changes in immune cell composition over time.

Inhibition of miR-214 expression by small molecules alleviates head and neck cancer metastasis by targeting ALCAM/TFAP2 signaling.

This study shows that inhibiting miR-214 with EGCG reduces head and neck cancer metastasis by targeting ALCAM/TFAP2 signaling.

Differentially deregulated microRNAs contribute to ultraviolet radiation-induced photocarcinogenesis through immunomodulation: An-analysis of microRNAs expression profiling.

This study identifies differentially expressed miRNAs in UVB-induced skin cancer and shows their role in immunomodulation and photocarcinogenesis.

Tumor microenvironments impair T cell receptor affinity and function

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.