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GeneticsbioRxiv
Preprint

An accurate genetic clock

D. H. Hamilton

Abstract

Molecular clocks give \"Time to most recent common ancestor\" TMRCA of genetic trees. By Watson-Galton17 most lineages terminate, with a few overrepresented singular lineages generated by W. Hamiltons \"kin selection\"13. Applying current methods to this non-uniform branching produces greatly exaggerated TMRCA. We introduce an inhomogenous stochastic process which detects singular lineages by asymmetries, whose reduction gives true TMRCA. This implies a new method for computing mutation rates. Despite low rates similar to mitosis data, reduction implies younger TMRCA, with smaller errors. We establish accuracy by a comparison across a wide range of time, indeed this is only clock giving consistent results for both short and long term times. In particular we show that the dominant European y-haplotypes R1a1a & R1b1a2, expand from c3700BC, not reaching Anatolia before c3300BC. While this contradicts current clocks which date R1b1a2 to either the Neolithic Near East4 or Paleo-Europe20, our dates support recent genetic analysis of ancient skeletons by Reich23.

02 /Specification & Classification

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David Hamilton·bioRxiv·Jun 19, 2015