Priya Moorjani

The study estimates mutation rates in Devils Hole pupfish, finding higher rates than expected for its small population size, contradicting the drift-barrier hypothesis.

The paper investigates how long-term small population size and inbreeding contribute to premature death in Devils Hole pupfish using genomic and phenotypic data.

TRACE identifies archaic ancestry using ancestral recombination graphs from contemporary genomes, revealing ghost admixture and challenging existing interpretations of archaic introgression.

This study evaluates kinship inference in sedimentary ancient DNA by simulating data and applying a heterozygosity-based test to identify multi-contributor samples.

The paper introduces sedimix, an open-source workflow for analyzing hominin nuclear DNA sequences from sediments, demonstrating high sensitivity and precision through simulations and comparisons to published studies.

This study analyzes South Asian genomes to understand the evolutionary history of lactase persistence, finding that Steppe ancestry, not selection, explains most LP prevalence, with exceptions in two pastoralist groups.

The paper identifies AD-associated genes in South Asians using whole-genome sequence data and variant analysis, finding associations for APOE, PICALM, and TSPOAP1 with cognitive function.

The paper analyzes Neandertal ancestry in over 300 genomes to determine the timing and impact of gene flow from Neandertals to modern humans.

This paper benchmarks genotyping and imputation methods for degraded DNA in forensic applications across diverse populations, finding that ATLAS outperforms conventional tools and that reference panel diversity improves accuracy.

This study analyzes 2,762 whole genome sequences from diverse Indian populations to reconstruct 50,000 years of evolutionary history, revealing major admixture events and archaic hominin gene flow.

The paper examines the effect of APOE ε4 and its interaction with sociodemographic factors on cognitive measures in South Asians from LASI-DAD, finding stronger associations in older adults and females.

The paper uses ancient DNA data to trace the genetic origins and spread of Indo-European languages in South and Central Asia.

The paper challenges the textbook view of germline mutations by showing that DNA damage and maternal age significantly contribute to mutation rates, with young fathers contributing more mutations than young mothers.

The paper examines the challenges in translating germline mutation rates from pedigrees to substitution rates, highlighting the need for detailed knowledge of mutation accumulation in development.

This paper introduces a genetic method using the recombination clock to date ancient human samples, showing it provides reliable age estimates for non-African genomes with Neanderthal ancestry.

This study identifies 81 unique South Asian populations with founder events leading to recessive diseases, highlighting opportunities for disease gene discovery and burden reduction.

The paper analyzes substitution rates across primate genomes and finds significant variation in molecular clocks between species and within hominoids, with CpG transitions showing more clock-like behavior.

This study reconstructs Austronesian population history in Island Southeast Asia using genome-wide data, revealing unexpected ancestry links to Austro-Asiatic populations.