Hugues Roest Crollius

The paper studies gene regulatory evolution in salmonids after autotetraploidization, finding that it is influenced by developmental and tissue-specific factors, with constraints at advanced embryogenesis.

This study benchmarks molecular dating accuracy for single gene trees, identifying factors like alignment length, rate heterogeneity, and selection pressure that affect divergence time estimation.

The paper constructs a high-resolution comparative atlas of paleopolyploid regions across 74 teleost genomes to study rediploidization and finds that some duplicated regions remained tetraploid for over 60 million years.

This paper introduces FINSURF, a machine learning tool that improves the prediction of pathogenic non-coding variants, achieving high accuracy in identifying disease-causing variants in clinical settings.

The paper identifies rare CRE variants associated with X-linked intellectual disability by combining sequencing, functional assays in zebrafish and mice, and phenotypic analysis.

The paper identifies conserved small nucleotide sequences that drive piRNA biogenesis from genes and lncRNAs, revealing a new regulatory pathway in insect and mammalian species.

SCORPiOs improves gene phylogenies in teleost fish by integrating syntenic information, resolving inconsistencies in 70% of gene families and enhancing congruence with species trees and expression patterns.

This study shows GC content influences mRNA decay, storage, and translation in human cells, with AU-rich mRNAs regulated at the translation level and GC-rich mRNAs at the decay level.

This study constructs enhancer-gene maps for human and zebrafish genomes using evolutionary conservation, revealing correlations between enhancer number and gene expression breadth, and identifying ancestral regulatory relationships.

The paper reconstructs the chromosome evolution of the ancestral vertebrate genome through two whole genome duplications and subsequent fusions, resolving ambiguities in the lamprey genetic map and providing insights into micro-chromosome origins.