Intrinsic structural disorder on proteins is involved in the interactome evolution

Abstract

New mathematical tools help to understanding cell functions, adaptability and evolvability to discover hidden variables to predict phenotypes that could be tested in the future in wet labs. Different models have been successfully used to discover properties of the protein-protein interaction network or interactome. We found that in the hyperbolic Popularity-Similarity model cellular proteins with highest contents of structural intrinsic disorder cluster together in many different eukaryotic interactomes and not the prokaryotic E. coli, where proteins with high levels of intrinsic disorder are very low. We also found that the normalized theta variable from the Popularity-Similarity model for a protein family correlate to the seniority of the organisms in analysis.