Frank Hause

Local fractal dimension as an indicator of functional reorganization in molecular interaction networks

The paper introduces DIFFRACT, a framework that uses local fractal dimension changes in protein interaction networks to detect functional reorganization, showing its utility in identifying novel biological roles in RAVER1-deficient cells.

Revisiting p53:Sirt1 interaction in the light of controlling p53 acetylation levels

This study presents the first structural model of the full-length p53:Sirt1 complex, showing Sirt1 selectively deacetylates p53 at K582 and binds acetylated p53 with a 1:1 stoichiometry.

Hyperbolic stratification of protein intrinsic disorder and structure-mediated interactions in the human protein interactome

The paper maps the human protein interactome onto a hyperbolic representation to analyze how intrinsic disorder and structure-mediated interactions influence network organization and molecular functions.

CENTRA: Knowledge-Based Gene Contexuality Graphs Reveal Functional Master Regulators by Centrality and Fractality

CENTRA uses gene co-occurrence networks from literature to identify functional master regulators by analyzing centrality and fractality in topic-specific contexts.

RNA-seq derived sequence variations are excellent features for cell line identification

This study shows RNA-seq-derived sequence variations can reliably identify cell lines and detect cross-contamination using machine learning.

Treatment Efficacy of Theophylline in ADYC5 Dyskinesia: A Retrospective Case Series Study

This study evaluates theophylline's efficacy in treating ADCY5-related dyskinesia, finding significant symptom improvement in 92% of patients with notable adverse effects.

Serum Proteome Profiling Identifies N-Cadherin and C-Met as Early Marker Candidates of Therapeutic Response to Neoadjuvant Chemotherapy in Breast Cancer

A Workflow for Improved Analysis of Cross-linking Mass Spectrometry Data Integrating Parallel Accumulation-Serial Fragmentation with MeroX and Skyline

This paper introduces a workflow for improved XL-MS data analysis using PASEF, integrating MeroX and Skyline for better identification of cross-linked products.