Andrea Sinz

The paper introduces DIFFRACT, a framework that uses local fractal dimension changes in protein interaction networks to detect functional reorganization, showing its utility in identifying novel biological roles in RAVER1-deficient cells.

This study identifies IGF2BP1 as a regulator of mitotic integrity in CRC, showing that its inhibition creates a therapeutic vulnerability that synergizes with paclitaxel.

This study presents the first structural model of the full-length p53:Sirt1 complex, showing Sirt1 selectively deacetylates p53 at K582 and binds acetylated p53 with a 1:1 stoichiometry.

The paper maps the human protein interactome onto a hyperbolic representation to analyze how intrinsic disorder and structure-mediated interactions influence network organization and molecular functions.

CENTRA uses gene co-occurrence networks from literature to identify functional master regulators by analyzing centrality and fractality in topic-specific contexts.

This study identifies TRIP13 as a developmentally restricted dependency in NUP98::KDM5A+ pediatric AML, showing that its inhibition reactivates TP53 and kills leukemic cells.

This study identifies FAM30A as a regulator of LSC function in AML by interacting with MSI2 and RUNX1, enhancing stemness and chemoresistance.

This study identifies IQD2 and KLCR1 as a module that promotes microtubule mechano-responsiveness in plant pavement cells by localizing to the plasma membrane-microtubule nexus.

This study evaluates theophylline's efficacy in treating ADCY5-related dyskinesia, finding significant symptom improvement in 92% of patients with notable adverse effects.

This paper introduces DSSI, a new class of MS-cleavable cross-linkers with affinity tags, and validates its use in structural biology.

This paper introduces a workflow for improved XL-MS data analysis using PASEF, integrating MeroX and Skyline for better identification of cross-linked products.

The paper identifies the Isc machinery as the source of iron for the Fe(CN)2CO group in [NiFe]-hydrogenases in E. coli, while the Suf machinery can deliver the [4Fe-4S] cluster to HypD.

This paper investigates RAVER1's role in controlling alternative splicing and its impact on miR/RISC activity and EMT in cancer cells.

The paper introduces a streamlined XLMS workflow and updated software tool for proteome-wide protein interaction analysis, demonstrating results in Drosophila embryos.

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.