Bridging the gap - Spontaneous fluctuations shape stimulus-evoked spectral power

Abstract

Spontaneous fluctuations of neural activity have been shown to influence trial-by-trial variation in perceptual, cognitive, and behavioural outcomes. This implies that these fluctuations affect stimulus-related neural processes, and hence should affect stimulus-evoked neural activity. However, the mechanisms by which spontaneous neural activity shapes stimulus-evoked neural activity have rarely been examined. Employing a large-scale magnetoencephalographic dataset, as well as an electroencephalographic replication dataset, we observed that for high-frequency power, high pre-stimulus activity leads to greater evoked desynchronization (negative interaction); in contrast, for low-frequency power, high pre-stimulus activity induces greater event-related synchronization (positive interaction). We show that both positive and negative interactions are manifest primarily in cortical oscillations, rather than scale-free activity, and can also be observed in the time domain. In summary, we demonstrate positive and negative spontaneous-evoked interaction in multiple electrophysiological processes; these mechanisms "bridge the gap" between spontaneous and evoked activity and provide novel insights into how spontaneous activity influences behaviour and cognition.