Earl K. Miller

Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia

The paper uses a mechanistic model to simulate propofol's effects on brain circuits, identifying a dose-dependent biomarker confirmed in empirical data.

Neural subspace reorganization reflects value-based decision making

The paper shows how value-based decisions reorganize neural subspaces in LPFC by rotating and expanding chosen option representations.

Disruption of interareal control during propofol anesthesia

This study uses control-theoretic methods to show that propofol anesthesia reduces interareal control in the brain, leading to a directional breakdown of cortical control.

BAYESIAN STATE-SPACE MODEL FOR JOINT INFERENCE OF OSCILLATORY DYNAMICS AND POINT-PROCESS COUPLING

This paper introduces a Bayesian state-space model to jointly infer oscillatory dynamics and spike-field coupling, showing improved frequency-specific estimates compared to classical methods.

Mechanistic corticostriatal circuit model predicts learning-dependent fMRI dynamics and individual reward bias in humans

The paper uses a biophysical corticostriatal model to predict fMRI dynamics and individual reward bias in humans, confirming predictions through fMRI data.

Low-dimensional prefrontal representations of objects during working memory

The paper investigates the dimensionality of prefrontal cortex representations during working memory and finds they are low-dimensional, compressed compared to visual inputs.

Theta gates and routes information in the frontal cortex

This study investigates how theta oscillations coordinate neural activity in the frontal cortex of non-human primates during a dot pattern categorization task, revealing directional routing and cross-frequency interactions.

Ephaptic coupling can explain variability in neural activity

The paper shows that ephaptic coupling from mesoscale electric fields explains trial-to-trial variability in cortical oscillatory power during a spatial delay saccade task.

Evidence for predictive computations in a brain hierarchy during a visual search task

The paper compares predictive coding, routing, and autoencoders using LFP data to determine their role in visual search task neural dynamics.

Similar destabilization of neural dynamics under different general anesthetics

The paper shows that different anesthetics destabilize neural dynamics similarly, affecting recovery and low-frequency power, and linking this to unconsciousness.

Decoding region-level visual functions from invasive EEG data

This study uses an artificial neural network to decode visual functions from invasive EEG data in monkeys, identifying region-specific roles in color, shape, and motion processing.

Emergent Traveling Waves in Neural Circuits

This study shows that traveling waves emerge in neural networks under biologically plausible constraints and support working memory, matching primate cortex recordings.

Oscillatory Control of Cortical Space as a Computational Dimension

The paper tests the Spatial Computing hypothesis by analyzing alpha/beta oscillations in non-human primates, finding they organize task-related information and constrain sensory expression in space.

Adaptive stretching of representations across brain regions and deep learning model layers

The paper shows that brain regions and deep learning models stretch representations along task-relevant dimensions to optimize performance through error minimization.

State-space trajectories and traveling waves following distraction

The paper shows that after distractions, neural activity in the prefrontal cortex returns to pre-disruption patterns through state-space rotations and traveling waves.

Working memory readout varies with frontal theta rhythms

The paper shows that working memory readout in the frontal eye field varies with theta rhythm phases, linked to performance in a visual memory task.

A ubiquitous spectrolaminar motif across independent studies, including in the Mackey et al. dataset

The paper reaffirms the ubiquity of a spectrolaminar motif across multiple datasets and introduces an improved tool to identify it.

Recycling of prefrontal subspaces dynamically multiplexes information

The paper shows that prefrontal cortex subspaces are reused across time and for different information types, challenging previous assumptions about their fixed roles.

Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations

This study shows that ketamine and dexmedetomidine induce similar cortical phase alignment patterns in nonhuman primates, suggesting a common mechanism for loss of responsiveness.

Evidence for an active handoff between cerebral hemispheres during target tracking

The paper investigates how cerebral hemispheres coordinate during target tracking, finding that alpha and theta power changes signal an active handoff of attention between hemispheres.

Quantifying Differences in Neural Population Activity With Shape Metrics

The paper introduces a framework for comparing neural population activity using shape distances, demonstrating its application across species and behavioral tasks.

Anterior cingulate neurons display subregion-specific interaction with frontal eye fields as revealed by combined antidromic stimulation and resting state imaging

This study combines electrophysiology and fMRI to show ACC neurons predominantly connect to medial FEF, with stronger functional connectivity during specific saccade tasks.

Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity

This study investigates how propofol-induced loss of consciousness affects neural oscillations and spiking activity in monkeys during auditory processing, finding disrupted alpha/beta inhibition and enhanced gamma/spiking.

Propofol anesthesia destabilizes neural dynamics across cortex

This study uses DeLASE to show that propofol anesthesia reduces dynamic stability in macaque cortex, mirroring destabilized linear systems.

Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors

This study shows how ketamine's effects on NMDA receptor kinetics lead to oscillatory brain dynamics observed in EEG and local field potential recordings.

A ubiquitous spectrolaminar motif of local field potential power across the primate cortex

The paper identifies a consistent spectrolaminar pattern of LFP power across primate cortex, showing distinct frequency gradients in superficial and deep layers.

Biomimetic model of corticostriatal micro-assemblies discovers new neural code

The paper introduces a biomimetic model that generates simulated neural activity and cognitive phenomena, validated against experimental data, and discovers a new neural code predicting erroneous behaviors.

Propofol Mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy

This study shows propofol disrupts sensory signal progression through the cortical hierarchy by affecting both Up and Down states, with persistent responses only in auditory cortex.

Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques

The paper demonstrates the use of multifunctional fibers to record and modulate neural activity in macaques during cognitive tasks, showing changes in neural activity with local inhibition.

In vivo ephaptic coupling allows memory network formation

The paper investigates how bioelectric fields contribute to memory network formation through in vivo ephaptic coupling using synergetics and machine learning.