Biological variation in the sizes, shapes and locations of visual cortical areas in the mouse

Jack Waters; Eric Lee; Nathalie Gaudreault; Fiona Griffin; Jérôme A. Lecoq; Cliff Slaughterbeck; David Sullivan; Colin Farrell; Jed Perkins; David Reid; David H. Feng; Nile Graddis; Marina Garrett; Yang Li; Fuhui Long; Chris Mochizuki; Kate Roll; Jun Zhuang; Carol L. Thompson

doi:10.1371/journal.pone.0213924

NeurosciencePLoS ONEMay 1, 2019

Peer-reviewed journal article

Biological variation in the sizes, shapes and locations of visual cortical areas in the mouse

Jack Waters iD, Eric Lee iD, Nathalie Gaudreault, Fiona Griffin iD, Jérôme A. Lecoq iD, Cliff Slaughterbeck iD, David Sullivan, Colin Farrell iD, Jed Perkins, David Reid iD, David H. Feng iD, Nile Graddis, Marina Garrett iD, Yang Li iD, Fuhui Long, Chris Mochizuki, Kate Roll iD, Jun Zhuang iD, Carol L. Thompson iD

Abstract

Visual cortex is organized into discrete sub-regions or areas that are arranged into a hierarchy and serve different functions in the processing of visual information. In our previous work, we noted that retinotopic maps of cortical visual areas differed between mice, but did not quantify these differences or determine the relative contributions of biological variation and measurement noise. Here we quantify the biological variation in the size, shape and locations of 11 visual areas in the mouse. We find that there is substantial biological variation in the sizes of visual areas, with some visual areas varying in size by two-fold across the population of mice.

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