Jun Zhuang

Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level

This study integrates molecular and morphological data to classify cortical neurons and map their connectomes, revealing organizational principles of brain-wide networks at the single-cell level.

Hebb's Vision: The Structural Underpinnings of Hebbian Assemblies

The paper identifies neural assemblies consistent with Hebb's theory using a novel dataset linking optical physiology to connectivity, finding they are structurally integrated but not defined by strong monosynaptic connections.

Motion/direction-sensitive thalamic neurons project extensively to the middle layers of primary visual cortex

The paper shows motion/direction-sensitive thalamic neurons project more to middle layers of V1 than previously thought, challenging existing views on thalamocortical organization.

Chandelier cell anatomy and function reveal a variably distributed but common signal

The paper maps chandelier cell synapses onto pyramidal neurons and finds variability in synaptic input correlated with target neuron features, while showing functional correlation with arousal state.

The spatial structure of feedforward information in mouse primary visual cortex

The paper maps the functional and structural properties of feedforward projections from the LGN to V1 in mice, revealing differences in receptive fields and depth-dependent biases between location-sensitive and motion-sensitive axons.

A large-scale, standardized physiological survey reveals higher order coding throughout the mouse visual cortex

The paper presents a large-scale dataset of neural activity in the mouse visual cortex and shows that responses to different stimuli are largely independent, suggesting multi-layer hierarchical computation.

Separation of hemodynamic signals from GCaMP fluorescence measured with widefield imaging

The paper develops a spatially-detailed regression model to separate hemodynamic signals from GCaMP fluorescence in widefield imaging of awake mice, improving accuracy near blood vessels and along the sagittal midline.

Biological variation in the sizes, shapes and locations of visual cortical areas in the mouse

The paper quantifies biological variation in the sizes, shapes, and locations of 11 visual cortical areas in mice, finding substantial size variation across the population.

Activation of neuromodulatory axon projections in primary visual cortex during periods of locomotion and pupil dilation

The paper observes that cholinergic and noradrenergic axons in the mouse primary visual cortex show increased activity during pupil dilation and locomotion, with fluorescence changes preceding and lasting beyond pupil dilation.

Aberrant Cortical Activity In Multiple GCaMP6-Expressing Transgenic Mouse Lines

The paper reports aberrant cortical activity and fluorescence events in some GCaMP6-expressing transgenic mice, suggesting potential artifacts in neuronal recordings.