Ben Vermaercke

Human synaptic neoteny requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition

The paper shows that human-specific genes SRGAP2B/C regulate synaptic neoteny in human cortical neurons by modulating SYNGAP1 levels.

SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo.

This study shows that SYNGAP1 deficiency causes accelerated synaptic development and disrupted neoteny in human cortical neurons transplanted into mice, linking it to ID/ASD.

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's Disease

The paper shows that astrocyte calcium dysfunction leads to early network hyperactivity in Alzheimer's Disease, which can be reversed by restoring calcium signaling.

Cellular organization of visual information processing channels in the mouse visual cortex

The paper characterizes the spatiotemporal tuning properties of over 30,000 neurons across seven mouse visual areas to reveal functional diversity and specialized visual processing channels.

Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits.

This study transplants human cortical neurons into mice to study their development and integration into mouse visual circuits, finding prolonged juvenile features and functional synaptic integration.