Investigating cortical buffering effects of acute moderate and light intensity exercise: a cTBS study targeting the left dorsolateral prefrontal cortex

Abstract

BackgroundThe beneficial effects of both single-session bouts of aerobic exercise and therapeutic exercise interventions on the cortical regions associated with executive functions (i.e., prefrontal cortex (PFC)) have been well documented. However, it remains unclear whether aerobic exercise can be used to offset temporary fluctuations in cortical activity. ObjectiveThe current study sought to determine whether a single session of moderate intensity aerobic exercise can offset the attenuating effects of continuous theta burst stimulation (cTBS) targeting the dorsolateral prefrontal cortex (dlPFC). MethodsTwenty-two right-handed participants between 18-30 years completed a 20 minute session of light intensity (10% heart rate reserve (HRR)) and moderate intensity (50% HRR) exercise in a counterbalanced order. Following each exercise session, participants received active cTBS to the left dlPFC. Changes in executive functions were quantified using a flanker paradigm employed at baseline, post-exercise and post-cTBS time points. Additionally, EEG methodologies were used to measure changes in inhibitory control specific event-related potential components (i.e., P3 and N2) in response to the flanker task. ResultsBehavioural results from the flanker task revealed a significant improvement in task performance following an acute bout of moderate intensity exercise. Furthermore, the effect of cTBS in both light and moderate intensity conditions were non significant Similarly, EEG data from P3 and N2 ERP components revealed no changes to amplitude across time and condition. P3 latency data revealed a significant effect of time in the light intensity condition, such that latency was faster following cTBS. Similarly, latency data within the N2 ERP component revealed a significant effect of time on congruent trials in the light intensity condition; N2 latency was faster following cTBS. ConclusionThe current study revealed that light and moderate intensity exercise may provide a buffer to cTBS-induced attenuation of the dlPFC. This study provides empirical and theoretical implications on the potential for exercise to promote cognitive control.