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DatabaseBioinformaticsPeer-reviewed journal article

CATA: a comprehensive chromatin accessibility database for cancer

Jianyuan Zhou, Yanshang Li, Jiaxin Chen, Taisong Li, Weijie ZhaniD, Jianmei Zhao, Meng Li, Rui YuiD, Zou Haiying, Wangkai FangiD, Qiuyu Wang, Jian‐Jun XieiD

PDFDOIPreprint

Abstract

Chromatin accessibility is a crucial epigenetic concept that plays a biological role in oncology. As humans become more involved in cancer research, a comprehensive database is required to identify and annotate tumor chromatin accessible regions (CARs). Here, CATA was developed to provide cancer-related CAR annotation. Currently, CATA possesses 2,991,163 CARs, relevant clinical data, and transcription factor binding predictions for cancer CARs from 410 tumor samples of 24 cancer types. Furthermore, CARs were annotated by SNPs, risk SNPs, eQTLs, linkage disequilibrium SNPs, transcription factors, CNV, SNV, enhancer, and 450K methylation sites in our database. By combining all these resources, we believe that CATA will provide better service for researchers on oncology. Our database is accessible at http://bio.licpathway.net/cata/Competing Interest StatementThe authors have declared no competing interest.View Full Text

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