Yuan He

The paper determines the cryo-EM structure of Pol λ bound to the short-range synaptic complex, revealing its recruitment mechanism and coordinated activity with PNKP in NHEJ end processing.

The paper performs genotype inference from aggregated chromatin accessibility data to identify caQTLs and their links to gene expression and complex traits.

GBAT improves detection of trans-gene regulation by addressing multiple testing, read-mapping biases, and confounders in eQTL analysis.

The paper reports the cryo-EM structure of the yeast SWI/SNF chromatin remodeling complex bound to a nucleosome, revealing its architecture and interactions with histones.

GTEx v8 maps expression and splicing QTLs in 49 tissues from 838 donors: cis-eQTLs cover 94.7% of protein-coding genes, and cross-tissue QTL sharing mirrors cell-type composition.