Author

Emin Onur Karakaslar

Leiden University Medical CenterORCID 0000-0002-9182-910XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Duygu UcariD· 2 shared Ahrim YouniD· 1 shared Akmal SalimoviD· 1 shared Caner SayginiD· 1 shared Cheng‐Han ChungiD· 1 shared Daniel Geoffrey TeneniD· 1 shared Erik B. van den AkkeriD· 1 shared Jacques BanchereauiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersSystems Biology

Duygu UcarORCID

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3 papers

Recent·Most cited

Human CEBPA-N AML exhibits enhanced engraftment and a C/EBPα-p30-driven leukemic stem cell program

Philomina Sona Peramangalam, Mayuresh Vishwas Konde, Emin Onur Karakaslar, Sebastian Wolf, Shikan Zheng, Akmal Salimov, Sridevi Surapally, Marieke Griffioen, Tongjun Gu, Sridhar Rao, Daniel Geoffrey Tenen, Thomas Oellerich, Erik B. van den Akker, Martin Carroll, Caner Saygin, John Anto Pulikkan

This study identifies CEBPA-N-AML as having enhanced engraftment and defines a novel LSC signature in CEBPA-N-AML.

bioRxiv · Aug 4, 2026 · PreprintCancer Biology

Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging

Emin Onur Karakaslar, Neerja Katiyar, Muneer G. Hasham, Ahrim Youn, Siddhartha M. Sharma, Cheng‐Han Chung, Radu Marcheş, Ron Korstanje, Jacques Banchereau, Duygu Ucar

The paper identifies the transcriptional activation of Jun and Fos genes in the AP-1 complex as a conserved aging signature in immune cells, contributing to inflammaging across mouse strains and humans.

Aging Cell · Feb 24, 2023Peer-reviewedSystems Biology

cinaR: A comprehensive R package for the differential analyses and functional interpretation of ATAC-seq data

Emin Onur Karakaslar, Duygu Ucar

cinaR provides an R package for differential chromatin accessibility analysis and functional interpretation of ATAC-seq data, integrating multiple analysis pipelines and visualization tools.

bioRxiv · Mar 5, 2021 · PreprintBioinformatics