The Conquering influence of the Nano extracts of pomegranate peels and pistachio leaves in amelioration of acute liver failure

Abstract

ObjectiveAcute liver failure (ALF) is a clinical condition with an unclear history of pathophysiology, making it a challenging task for scientists to reverse the disease in its initial phase and to help the liver re-function as usual: this study was proposed to estimate the hepatoprotective effects of Punicagranatum peel and Pistaciaatlantica leaves as a multi-rich antioxidants ingredients either in their normal and/or in their nano forms against thioacetamide induced acute liver failure in a rodent model. MethodSixty male Wistar rats were divided into six equal groups, the first group employed as a control; the second group was given a dose of thioacetamide (TAA)-350 mg/bwip., from the third to the sixth group received TAA {square} 2ml of 100gm of aqueous extracts of PunicagranatumL and Pistaciaatlantica either in their normal and/or Nano forms consecutively along 2 weeks. Resultsrecorded significant elevation in liver enzymes, lipid profiles, LPO and NO with marked significant decrease in GSH and SOD accompanied by elevation in inflammatory cytokine (IL6,TNF- and AFP) in addition to a noticeable increase in HSP70 level & degradation in DNA respectively in TAA challenged group. However significant and subsequent amelioration of most of the impaired markers has been observed with ipnano treatment of both extracts. ConclusionThe current results highlighted the high performance of both plant nano extracts and their hepatoprotective impact and their possible therapeutic role in the amelioration of TAA induced acute liver failure in experimental animals.