Design and Preparation Of A Novel Hydrogel Based An Maleimide Thiol Conjugation

Abstract

This article synthesized and characterized a novel hydrogel, which is formed using maleimide-thiol conjugation. Two precursors chitosan functionalized thiol groups and dextran functionalized maleimide groups prepared and characterized by NMR. The hydrogel studied by gelation time, swelling studies, viscoelastic properties, degradation rate. From gelation time result, we found that formed hydrogel gelation time could be changed with diffident weight percentage of precursors. Based on references, we found the best formular for the gelation and it was also determined for other studies. The swelling study indicated hydrogel has good flexibility and the degradation test indicated hydrogel is biodegradable. The viscoelastic test indicated hydrogel is elastic solid. From these studies, this a novel hydrogel could be potential for biomedical applications.