G. Duncan

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

This study maps human bone marrow niches using single-cell transcriptomics and proteomic imaging, identifying distinct cellular environments and their roles in hematopoiesis and AML.

Mucus physically restricts influenza A viral particle access to the epithelium

This study shows mucus traps influenza A virus through physical barriers, not just sialic acid binding, and synthetic hydrogels with similar structures can block infection.

Engineering in vitro models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials

This study develops synthetic NET-like biomaterials to model CF lung disease, showing they increase mucus viscoelasticity and promote bacterial growth.

Synthetic mucus biomaterials for antimicrobial peptide delivery

This study develops synthetic mucus hydrogels to deliver antimicrobial peptides, showing prolonged activity against Pseudomonas aeruginosa compared to free peptides.

A virus-induced circular RNA maintains latent infection of Kaposi sarcoma herpesvirus

This study identifies a virus-induced circular RNA, hsa_circ_0001400, that promotes KSHV latency by inhibiting lytic replication and enhancing cell survival.

Machine Learning Informed Predictions of Nanoparticle Mobility and Fate in the Mucus Barrier

This study uses machine learning to classify nanoparticle diffusion modes in mucus and predicts their transport and fate.

Natal and adult dispersal among four elephant seal colonies

The paper quantifies natal and adult dispersal patterns in elephant seals across four colonies, finding high female dispersal from the southernmost colony and low adult dispersal.

Influenza A virus diffusion through mucus gel networks

This study quantifies influenza A virus diffusion through human airway mucus, finding that mesh structure, not neuraminidase activity, primarily influences virus mobility.

Disulfide disruption reverses mucus dysfunction in allergic airway disease

This study shows that reducing disulfide bonds in mucins reverses mucus dysfunction in asthma by improving mucociliary clearance and reducing airway hyperreactivity.

Designing viscoelastic mucin-based hydrogels

This study designs mucin-based hydrogels with viscoelastic properties similar to native mucus using thiol-based cross-linking.