S. Jiang

A new yeast-based bioreporter for simple, sensitive, and cost-effective detection of dioxin-like compounds

This study develops a yeast-based bioreporter, DnaSc, for sensitive and cost-effective detection of dioxin-like compounds and AhR agonists with a detection limit of 10 fM for TCDD.

Viral diversiy within marine biofilms and their potential roles in microbially influenced corrosion

This study analyzes viral communities in marine biofilms on 8 materials to explore their roles in microbially influenced corrosion, finding viruses influence corrosion through interactions with corrosive microbes.

Realigning representational drift in mouse visual cortex by flexible brain-machine interfaces

This study uses flexible electrodes to track and model representational drift in mouse visual cortex, enabling a stable decoder for brain-machine interfaces.

Interplay between particle size and microbial ecology in the gut microbiome

This study investigates the factors influencing fecal particle size in humans and finds that gut microbiota, rather than diet or behavior, primarily shape particle size.

Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly

This paper introduces a soft-lithography-based acoustic bioassembly technique to create complex multicellular structures with functional liver tissue mimic capabilities.

Microbial cancer immunotherapy reprograms hematopoietic stem cells to enhance anti-tumor immunity

This study shows that bladder BCG immunotherapy reprograms hematopoietic stem cells to enhance anti-tumor immunity in mice and humans.

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

This study uses spatial multi-omics to compare EBV-positive and EBV-negative cHL, identifying distinct TME features and immunological signatures linked to EBV.

A Spatial Multi-Modal Dissection of Host-Microbiome Interactions within the Colitis Tissue Microenvironment

This study introduces MicroCart, a framework for spatial multi-omics analysis of host-microbiome interactions in colitis, revealing tissue-level immune responses and microbial shifts.

Robust Neutralization of SARS-CoV-2 Variants Including JN.1 and BA.2.87.1 by Trivalent XBB Vaccine-Induced Antibodies

The paper compares antibody responses from individuals with XBB reinfection and those vaccinated with WSK-V102C, showing the vaccine induces stronger neutralization against SARS-CoV-2 variants including JN.1 and BA.2.87.1.

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

This paper creates a spatial cell atlas of neuroblastoma, revealing tumor heterogeneity through multi-omics data and identifying spatial compartmentalization and signaling patterns.

Investigation of Biomedical Cell Image Cryptography Based on RC4 Technique

The paper applies RC4, pixel shuffling, and steganography to encrypt biomedical cell images and evaluates their performance using cell viability, live/dead ratio, and morphology.

Investigation of Two-Component Hydrogel System for the Tissue Regeneration from Simulation

The paper develops a computational model to simulate a two-component hydrogel system's behavior and assesses its impact on cell growth for tissue regeneration.

Integrated Hfq-interacting RNAome and transcriptomic analysis reveals complex regulatory networks of nitrogen fixation in root-associated Pseudomonas stutzeri A1501

This study identifies Hfq-binding RNAs in Pseudomonas stutzeri A1501 using eCLIP-seq, revealing new regulatory targets involved in nitrogen fixation and other metabolic processes.

Deep Learning Model Imputes Missing Stains in Multiplex Images

The paper introduces a deep learning model, MAXIM, to impute missing protein markers in multiplex images, improving efficiency in staining and imaging processes.

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Alterations in Epithelial Integrity

This study uses scRNA-seq to analyze DCIS and normal breast tissue, identifying clonal heterogeneity and cell state changes associated with progression to invasive cancer.

The inhibitory mechanism of a small protein reveals its role in antimicrobial peptide sensing

This study reveals how the small protein MgrB inhibits the sensor kinase PhoQ, modulating bacterial virulence and antimicrobial peptide sensing.

Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

Geranylgeranyl pyrophosphate (GGPP) is associated with hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4

This study shows GGPP promotes hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4, and inhibiting GGPP synthase reduces these effects.

Enhanced neutralization of SARS-CoV-2 XBB sub-lineages and BA.2.86 by a tetravalent COVID-19 vaccine booster

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

Large-scale lensless microscopy with fast acquisition and region-wise focusing

This paper develops a fast acquisition and region-wise focusing strategy for lensless microscopy, achieving high-resolution imaging of biological samples with reduced acquisition and reconstruction times.

Increased beta2-adrenergic signaling is a targetable stimulus essential for bone healing by promoting callus neovascularization

This study identifies beta2-adrenergic signaling as a key driver of bone healing by enhancing callus neovascularization, with implications for therapeutic strategies and the risks of beta-blockers.

Immune-Epithelial Dynamics and Tissue Remodeling in Chronically Inflamed Nasal Epithelium via Multi-scaled Transcriptomics

This study uses multi-scaled transcriptomics to investigate immune-epithelial dynamics and tissue remodeling in chronic rhinosinusitis, identifying novel cellular interactions and trajectories associated with nasal polyps.

The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation

This study identifies the molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation by analyzing cleavage specificity across species.

MAPS: Pathologist-level cell type annotation from tissue images through machine learning

MAPS provides pathologist-level cell type annotation from spatial proteomics data using machine learning, outperforming existing methods in speed and accuracy.

Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

This study shows that warming and altered precipitation independently and together reduce alpine soil microbial growth by 40-90%, with some taxa showing increased growth under specific climate conditions.

A single-cell atlas of the single versus multiple parous Hu Sheep ovary

This study constructs a single-cell atlas of Hu sheep ovaries comparing high-litter (HLS) and low-litter (LLS) sheep, identifying molecular differences in granulosa cells that affect reproductive outcomes.

Design and Preparation Of A Novel Hydrogel Based An Maleimide Thiol Conjugation

This paper synthesizes and characterizes a novel hydrogel using maleimide-thiol conjugation, showing it has good flexibility, biodegradability, and elastic properties, making it suitable for biomedical applications.

Single-Cell Map of Dynamic Multicellular Ecosystem of Radiation-Induced Intestinal Injury

This study maps the dynamic multicellular ecosystem of radiation-induced intestinal injury using single-cell RNA sequencing, revealing heterogeneous radiosensitivities and cellular interactions.

Neutralization of SARS-CoV-2 BQ.1.1 and XBB.1.5 by Breakthrough Infection Sera from Previous and Current Waves in China

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.

Multifunctional ferromagnetic fiber robots for navigation, sensing, and treatment in minimally invasive surgery

This paper introduces multifunctional ferromagnetic fiber robots capable of navigation, sensing, and treatment in minimally invasive surgery, demonstrating their use in electrophysiology sensing and localized treatment.