Wide dynamic range of contrast-encoding in neural responses in macaque V1

Abstract

The dynamic range of contrast-encoding in the early visual system has been investigated at both single-neuron and population levels in animals using oriented stimuli such as gratings and Gabor patches. However, contrast-encoding of unoriented stimuli such as Gaussians has been less explored, even though such stimuli can evoke a large population response. In studies that employ Gaussians, contrast response functions (CRFs) of neurons and neural populations in primary visual cortex are typically characterized across a limited range of Weber contrasts up to 100%, which may not adequately reflect the statistics of contrast in natural scenes. Indeed, our analysis shows that locations with contrasts far exceeding 100% Weber contrast are ubiquitous in natural scenes. Thus, our current understanding of contrast encoding remains incomplete in the context of natural environments. Here, we measured spiking activities of individual neurons using electrophysiology and population responses using calcium imaging in V1 of fixating macaques while Gaussian stimuli were presented over a wide range of Weber contrasts, up to 900%. Both the average spiking response and the average population response continued to increase robustly above 100% Weber contrast. Only a small minority of neurons saturate below 100% Weber contrast. These results demonstrate that the dynamic range of contrast-encoding in V1 is broader than previously assumed and aligns more closely with the statistics of contrast in natural scenes. Significance StatementThe dynamic range of contrast-encoding in V1 has typically been characterized using only a limited range of contrasts, often excluding the high contrasts commonly found in natural scenes. We measured contrast response functions of individual neurons and neural populations in V1 across a much wider range of contrasts. We found that the responses of the majority of neurons, as well as the overall population, increased robustly up to extremely high contrasts. These findings suggest that the dynamic range of contrast encoding in V1 extends well beyond the commonly tested range.