Gregory D. Horwitz

Robust and accessible in situ sequencing with an open-source automated sequencer

The paper introduces Seq-o-Matic, an open-source automated in situ sequencer that reduces hands-on time and improves sequencing consistency across tissue sections.

Cell type-selective AADC expression reduces motor deficits and dyskinesia in Parkinson's disease mouse models

This study shows that cell type-specific AADC expression in Parkinson's disease models reduces motor deficits and dyskinesia more effectively than broad targeting.

A flexible quality metric for electrophysiological recordings across brain regions and species

The paper introduces a new quality metric for electrophysiological recordings that adapts to varying refractory period durations across brain regions and species.

A Cross-Species Enhancer-AAV Toolkit for Cell Type-Specific Targeting Across the Basal Ganglia

The paper develops a cross-species enhancer-AAV toolkit for targeting specific cell types in the basal ganglia across species, validated in mouse and macaque.

OpenIrisDPI: An Open-Source Digital Dual Purkinje Image Eye Tracker for Visual Neuroscience

OpenIrisDPI is an open-source eye tracker that uses dual Purkinje image tracking to improve gaze estimation accuracy compared to traditional pupil-CR methods.

Closed-loop optogenetic perturbation of macaque oculomotor cerebellum: evidence for an internal saccade model

This study uses optogenetic stimulation to investigate cerebellar roles in saccade production, finding directional differences in how the oculomotor vermis contributes to forward and inverse models of eye movement.

Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species

The paper develops AAV-based genetic tools to specifically target astrocytes and oligodendrocytes across species, revealing functional roles in reward-dependent acetylcholine responses.

Deficits in decision-making induced by parietal cortex inactivation are compensated at two time scales

This study shows that inactivating the lateral intraparietal area in monkeys leads to decision-making deficits that are compensated for quickly within sessions and more slowly across sessions.

Coding of chromatic spatial contrast by macaque V1 neurons

This study investigates how macaque V1 neurons encode chromatic spatial contrast, finding that many use a weighted sum mechanism similar to simple cells.

Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse

The paper compares cellular diversity in the primary motor cortex across human, marmoset, and mouse using single-nucleus transcriptomics and epigenomics, finding conserved cell types and species-specific adaptations.

Single-cell RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates and humans

The paper uses single-cell RNA-seq to analyze relay neurons in the dLGN across species, finding subtle transcriptomic differences compared to morphological and functional distinctions.

Temporal filtering of luminance and chromaticity in macaque visual cortex

The paper measures cortical contributions to luminance and chromatic temporal contrast sensitivity in macaque monkeys and shows differences are mainly due to pre-cortical mechanisms.

Spatial receptive field structure of double-opponent cells in macaque V1

This study maps the spatial receptive fields of double-opponent cells in macaque V1 using dynamic white noise patterns, finding that Gabor functions better describe their structure than traditional models.

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

The paper identifies enhancer elements that drive subclass-specific gene expression in neocortex across mouse, primate, and human species using comparative epigenetics and AAV-based functional assays.

Focal optogenetic suppression in macaque area MT biases direction discrimination and choice confidence, but only transiently

This study uses optogenetic suppression in macaque area MT to examine its effects on direction discrimination and choice confidence, finding transient behavioral impacts.

Dethroning the Fano Factor: a flexible, model-based approach to partitioning neural variability

The paper introduces a flexible model-based approach to analyze neural variability, showing that many neurons exhibit non-quadratic mean-variance relationships and demonstrating improved adaptive stimulus selection.