Mario Dipoppa

Parvalbumin interneuron maturation reorganizes cortical population activity structure during development

This study shows that parvalbumin interneurons drive cortical network desynchronization and increased population activity dimensionality during development.

Dynamic recruitment of PV interneurons in the somatosensory cortex induced by experience dependent plasticity

This study investigates how PV interneuron activity changes in the somatosensory cortex during whisker trimming and shows that modulating PV activity alters microcircuit dynamics.

A universal power law optimizes energy and representation fidelity in visual adaptation

The paper explains a universal power law in visual adaptation as a trade-off between representation fidelity and energy cost using a computational model.

Circuit-Based Understanding of Fine Spatial Scale Clustering of Orientation Tuning in Mouse Visual Cortex

The paper investigates spatial organization of orientation tuning in mouse visual cortex and identifies micro-clustered organization of orientation preference.

Adaptation shapes the representational geometry in mouse V1 to efficiently encode the environment

The paper shows adaptation increases discriminability of frequent stimuli in mouse V1 by reshaping population response geometry, despite reduced individual neuron responses.

Contrast gain control is a reparameterization of a population response curve

The paper shows that contrast gain control can be viewed as a reparameterization of a population response curve, invariant across environments.

On the contrast response function of adapted neural populations

The paper shows that the population response magnitude in primary visual cortex follows a separable power-law combining stimulus intensity and probability.

A power law of cortical adaptation

The paper shows that neural population responses adapt to sensory environments with power law scaling of response magnitudes and invariant directions, enabling efficient signal transmission and metabolic adjustment.

A transcriptomic axis predicts state modulation of cortical interneurons

The paper identifies a transcriptomic axis that predicts how cortical interneurons modulate activity across brain states.

The combination of feedforward and feedback processing accounts for contextual effects in visual cortex

The paper develops a circuit model showing how feedforward and feedback processing in mouse V1 explain three contextual effects in visual responses.

A human-specific modifier of cortical circuit connectivity and function improves behavioral performance

This study shows that the human-specific gene SRGAP2C increases cortico-cortical connectivity and improves sensory processing and behavioral performance in mice.

Partitioning variability in animal behavioral videos using semi-supervised variational autoencoders

This paper introduces a video analysis tool that combines supervised pose estimation with unsupervised dimensionality reduction to extract interpretable behavioral features from animal videos, improving downstream analyses.

A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex

The paper identifies a disinhibitory circuit in mouse visual cortex that modulates responses based on stimulus-surround similarity.

Understanding the functional and structural differences across excitatory and inhibitory neurons

The paper uses an artificial neural network to study why excitatory and inhibitory neurons differ in selectivity and connectivity, finding that these differences can be explained by a few factors.

Vision and locomotion shape the interactions between neuron types in mouse visual cortex

The paper examines how locomotion affects neuron interactions in mouse visual cortex, finding that it alters synaptic connectivity rather than just disinhibition.

Suite2p: beyond 10,000 neurons with standard two-photon microscopy

Suite2p processes two-photon calcium movies faster than real time on desktop workstations, roughly doubling curated cell yield over CNMF and recovering 13,451 neurons in one session.