Interactive Data Integrator for Uniform Data Processing in the MorPhiC Program

Abstract

We present an interactive Data Integrator to facilitate uniform data processing and integration with datasets generated by the NIH funded MorPhiC (Molecular Phenotypes of Null Alleles in Cells) program. In the dataset identification step, users can select published bulk RNA sequencing (RNA-seq) datasets generated by the MorPhiC program, specify external datasets from the Gene Expression Omnibus (GEO) repository, or upload raw RNA-seq data. Subsequently, users can select a subset of samples and indicate experimental design by assigning groups to samples. External data will then be processed using the MorPhiC approved bulk RNA-seq analytical pipeline, and differential expression will be inferred. Users also have the option to download the uniformly processed counts table.