PHIST: fast and accurate prediction of prokaryotichosts from metagenomic viral sequences

Abstract

SummaryPHIST (Phage-Host Interaction Search Tool) predicts prokaryotic hosts of viruses from their genomic sequences. It improves host prediction accuracy at species level over current alignment-based tools (on average by 3 percentage points) as well as alignment-free and CRISPR-based tools (by 14-20 percentage points). PHIST is also two orders of magnitude faster than alignment-based tools making it suitable for metagenomics studies. Availability and implementationGNU-licensed C++ code wrapped in Python API available at: https://github.com/refresh-bio/phist Contactandrzej.zielezinski@amu.edu.pl, adam.gudys@polsl.pl Supplementary informationSupplementary data are available at publisher Web site.