Jie Ren

Macrocycle screening against the C-terminal region of CHD4 uncovers its role as an interaction hub in the formation of the nucleosome remodeling and deacetylase complex

The paper identifies macrocyclic peptides that disrupt the CHD4-GATAD2A interaction in NuRD, revealing CHD4's role as an interaction hub and suggesting a therapeutic strategy for beta-hemoglobinopathies.

Exploring the diversity of anti-defense systems across prokaryotes, phages, and mobile genetic elements

The paper develops AntiDefenseFinder to detect anti-defense systems in prokaryotes, phages, and MGEs, identifying 47,981 systems and revealing their distribution and evolutionary dynamics.

A network-based integrated framework for predicting virus-host interactions

The paper introduces a network-based framework to predict virus-host interactions, achieving higher accuracy than previous methods and expanding known interactions across diverse datasets.

Metagenomic unmapped reads provide important insights into human microbiota and disease associations

The paper introduces MicroPro, a metagenomic analysis tool that improves disease association predictions by including reads from unknown organisms, and identifies new microbial and viral associations with colorectal cancer, type-2 diabetes, and liver cirrhosis.