Limited Volumetric Separation Across CDR Groups in OASIS-1

Kendra Zimmermann; Shaurya Mahajan; Diana Sayadyan; Roman Peralta; Paulyn Tameze; Matthew Gonzalez; Luka Oushana; Sanjay Thunga; Noah St Clair

doi:10.64898/2026.05.27.728320

NeurosciencebioRxivMay 29, 2026

Preprint

Limited Volumetric Separation Across CDR Groups in OASIS-1

Kendra Zimmermann iD, Shaurya Mahajan iD, Diana Sayadyan iD, Roman Peralta iD, Paulyn Tameze iD, Matthew Gonzalez iD, Luka Oushana iD, Sanjay Thunga iD, Noah St Clair iD

PDF DOI

Post to X

Threads on X Post to Bluesky Threads on Bluesky

Abstract

Clinical Dementia Rating (CDR) scores are used to classify the cognitive state of patients and are provided within neuroimaging datasets. This is achieved through a standardized clinical assessment that evaluates participants cognitive and functional abilities in everyday life, after which they are given a score ranging from 0 to 3. Where 0 represents no signs of dementia and three represents severe dementia1. These scores are then used to track the progression of dementia over time2. This study explored if these CDR labels within the OASIS-1 dataset produced consistent volumetric separation across the hippocampus, amygdala, and cortex.