Bryan Andrew Strange

Hippocampal and Midbrain Function in Superagers Relates to Memory for Novelty and Expectation Violation

This study investigates whether preserved hippocampal-midbrain function during novelty and expectation processing underlies superior memory in superagers compared to typical older adults.

Emotional amnesia in humans with focal temporal pole lesions

The paper shows that left ventral temporal pole lesions impair verbal emotional memory but not neutral memory, while right lesions affect visual emotional memory, highlighting a lateralized role in emotional memory.

NAc-DBS selectively enhances memory updating without effect on retrieval

This study shows that NAc-DBS enhances long-term memory encoding without affecting memory recall or working memory in rats.

Genetic dissection of hippocampal sclerosis of ageing using magnetic resonance imaging surrogates

The paper investigates the association between Alzheimer's disease SNPs and hippocampal sclerosis of aging using MRI surrogates in a cohort of non-demented individuals.

Superagers resist typical age-related white matter structural changes

The paper examines white matter microstructure differences between superagers and typical older adults over five years, finding slower age-related changes in superagers.

Machine learning prediction of future amyloid beta positivity in amyloid-negative individuals

This paper predicts future amyloid beta positivity in amyloid-negative individuals using machine learning with non-invasive measures, finding better performance with CSF-based definitions.

Three-dimensional histology reveals dissociable human hippocampal long axis gradients of Alzheimer's pathology

The paper introduces Path2MR, a pipeline for 3D histology reconstruction without MRI, revealing distinct tau and amyloid-beta pathology gradients along the hippocampal axis in Alzheimer's Disease.

Retrieval of human aversive memories involves reactivation of gamma activity patterns in the hippocampus that originate in the amygdala during encoding

The paper shows that during retrieval of aversive memories, the hippocampus reactivates gamma activity patterns from encoding, which originate in the amygdala, suggesting a hippocampus-centered mechanism for memory retrieval.

Human hippocampal ripples tune cortical responses in uncertain visual contexts

The paper shows that hippocampal ripples predict visual stimulus unpredictability and modulate cortical responses in humans.

Hippocampal sclerosis of aging at post-mortem is evident on MRI more than a decade prior

This study shows hippocampal sclerosis of aging (HS) causes detectable hippocampal volume changes on MRI more than a decade before death, independent of age and Alzheimer's Disease burden.

A novel histological staging of hippocampal sclerosis that is evident in grey matter loss in vivo.

The paper develops a histological staging system for hippocampal sclerosis (HS) and shows its correlation with disease duration, cognitive performance, and MRI findings.

Brain Structure and Episodic Learning Rate in Cognitively Healthy Ageing

The paper examines the relationship between episodic learning rate and brain structure in older adults, finding associations with hippocampal volume and white matter integrity.

APOE ε4 effects on hippocampal atrophy in the healthy elderly reflect future cognitive decline

This study shows that APOE ε4's effect on hippocampal atrophy in healthy elderly is linked to future cognitive decline rather than genotype alone.

A gradient of electrophysiological novelty responses along the human hippocampal long axis.

The paper shows a gradient of electrophysiological novelty responses along the human hippocampal long axis, with theta frequency oscillatory power increasing from anterior to posterior.

Quantitative longitudinal predictions of Alzheimer's disease by multi-modal predictive learning

This paper predicts Alzheimer's disease progression using multi-modal data and predictive learning models, showing better performance than single-modal approaches.

Unmasking selective path integration deficits in Alzheimer's disease risk carriers

The paper identifies selective path integration deficits in Alzheimer's disease risk carriers using virtual navigation tasks and fMRI, linking them to grid cell dysfunction in the entorhinal cortex.

Predicting the future development of mild cognitive impairment in the cognitively healthy elderly

The paper identifies reduced grey matter density in the left entorhinal cortex as a biomarker for predicting mild cognitive impairment in cognitively healthy elderly individuals.

Toward a unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

The paper identifies a common neural tract associated with treatment response in OCD patients undergoing DBS targeting different brain regions.

Deep Brain Stimulation: Imaging on a group level

This paper introduces Lead Group, a tool for group-level DBS imaging analysis, showing optimal DBS targets in the dorsolateral STN and a fiber bundle linked to clinical outcomes in Parkinson's disease.

Action boosts episodic memory encoding in humans via engagement of a noradrenergic system.

The paper shows that taking action (Go-response) enhances episodic memory encoding compared to action inhibition (NoGo), mediated by the noradrenergic system.