Christine Löchner

Mapping Higher-Order Topology in OCD Brain Networks with Hodge Laplacian

This paper introduces a Hodge-Laplacian framework to analyze higher-order topology in OCD brain networks, identifying loop-level abnormalities not detectable by conventional functional connectivity analysis.

Genome-Wide Association Analysis of Tic Disorders Reveals 6 Independent Risk Loci and Highlights Tic-Associated Cell Types and Brain Circuitry

This study identifies six genome-wide significant risk loci for tic disorders and links genetic risk to specific brain cell types and circuits.

Shared genetic architecture of brain age gap across 30 cohorts worldwide

This study identifies a shared genetic factor underlying brain age gaps across 30 cohorts, finding 19 SNPs and associations with health traits.

Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium

This study analyzes fMRI data from OCD patients and controls to identify neural activation patterns during executive control tasks, finding reduced activation in frontoparietal regions and increased default mode network activity in OCD.

Specific amygdala and hippocampal subfield volumes in social anxiety disorder and their relation to clinical characteristics; an international mega-analysis

This study identifies specific amygdala and hippocampal subfield volume differences in social anxiety disorder compared to healthy controls, with associations to comorbid conditions.

Hippocampal and amygdala subfield volumes in obsessive-compulsive disorder differ according to medication status.

The paper examines hippocampal and amygdala subfield volumes in OCD patients and healthy controls, finding differences based on medication status.

Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.

White Matter Microstructure and its Relation to Clinical Features of Obsessive-Compulsive Disorder: Findings from the ENIGMA OCD Working Group

This study identifies white matter microstructural alterations in adult OCD patients and links them to clinical features, while finding no such abnormalities in pediatric patients.

Genome-wide Association Study of Pediatric Obsessive-Compulsive Traits: Shared Genetic Risk between Traits and Disorder

This study identifies a genome-wide significant variant for OC traits and shows shared genetic risk between OC traits and OCD.

Greater male than female variability in regional brain structure across the lifespan

The paper analyzes sex differences in brain structure variability across the lifespan using a large dataset, finding greater male variability in subcortical volumes, cortical surface area, and thickness in most regions.

Genome-wide analyses indirectly implicate miRNA regulatory mechanisms in Obsessive-compulsive Disorder psychopathology

The paper investigates miRNA regulatory mechanisms in OCD by analyzing genetic variants from a meta-analysis and identifies potential indirect miRNA targets associated with OCD risk.

Concordance Of Genetic Variation That Increases Risk For Tourette Syndrome And That Influences Its Underlying Neurocircuitry

This study identifies genetic overlaps between Tourette Syndrome risk and subcortical brain volumes using GWAS and pleiotropy analysis.