mutSigMapper: an R package to map spectra to mutational signatures based on shot-noise modeling

Abstract

SummarymutSigMapper aims to resolve a critical shortcoming of existing software for mutational signature analysis, namely that of finding parsimonious and biologically plausible exposures. By implementing a shot-noise-based model to generate spectral ensembles, this package addresses this gap and provides a quantitative, non-parametric assessment of statistical significance for the association between mutational signatures and observed spectra. Availability and implementationThe mutSigMapper R package is available under GPLv3 license at https://github.com/juliancandia/mutSigMapper. Its documentation provides additional details and demonstrates applications to biological datasets.