bioRxivCancer BiologyPreprint
DSPE-PEG-CeO2 inhibits tumor cell proliferation by inducing oxidative stress and cell death
Abstract
SUMMARYCeO2 can consume intracellular reducing power, but its poor biocompatibility limits its application in tumor therapy. In this study, we designed and synthesized DSPE-PEG-CeO2, which is easy to enter cells, and showed that DSPE-PEG-CeO2 can induce the increase of ROS levels in tumor cells, thereby inducing tumor cell apoptosis and DNA damage. This suppresses the appearance and development of tumor cells. This provides a new idea for the application of inorganic nanomaterials.
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Copper oxide nanoparticles function as antineoplastic agents in uterine cancer cell lines
Jordan D Berezowitz, Claire E. Rowlands, … Brittany E. Givens·bioRxiv·Jun 10, 2026
- MgO nanoparticles coated with Polyethylene Glycol as carrier for 2-Methoxyestradiol anticancer drug.
A. Alfaro, A. Leon, … p. orihuela·bioRxiv·Mar 25, 2019
- AIE nanoparticles camouflaged with tumor cell-derived exosomes for NIR-II imaging-guided photothermal therapy
- Enantiomer-Dependent Biological Activity of Cysteine-Coated Ceria Nanoparticles in Colorectal Cancer Cells
Emine Sumeyra Turali Emre, Ahmet Dinc, … Nicholas A. Kotov·bioRxiv·Apr 30, 2026
- Ozone mediates tumor-selective cell death caused by air plasma-activated medium independently of NOx
Y. Suzuki-Karasaki, M. Suzuki-Karasaki, … H. Nakayama·bioRxiv·Mar 17, 2023
- Nanoparticle-Functionalized Acrylic Bone Cement for Local Therapeutic Delivery to Spinal Metastases
A. Siddique, M. E. Cooke, … D. H. Rosenzweig·bioRxiv·Feb 6, 2023