Admixed and single-continental genome segments of the same ancestry have distinct linkage disequilibrium patterns

Abstract

BackgroundAdmixed populations offer valuable insight into the genetic architecture of complex traits. Many studies have proposed methods for genome-wide association study (GWAS) in admixed populations and various simulation studies have evaluated their performances. In this work, we propose another direction of comparison of recently proposed methods for admixed GWAS from a population genetic viewpoint. ResultsOur theoretical approach mathematically and directly compares the power of methods given that the causal variant is tested. This is done by deriving the variance formula of the methods from the population genetic admixture model. Our results analytically confirm previous observation that the standard GWAS test is more powerful than alternative tests due to leveraging allele frequency heterogeneity in which alternatives do not. As a by-product, we obtain a simple method to improve the power of multi-degrees-of-freedom tests only using summary statistics. We further investigate the problem when the causal variant is not directly known but is detected by tagging variants in linkage disequilibrium (LD). The analysis shows that a genetic segment from admixed genomes may exhibit distinct LD patterns from the single-continental counterpart of the same ancestry. ConclusionsWhile the classic admixture model is successful in predicting GWAS power, its popular extension in the literature falls short in explaining the LD patterns found in simulations and real data, warranting an improved model for LD in admixed genomes.