Line Skotte

An atlas of transcriptional dynamics in maternal blood over the course of healthy pregnancy

The paper presents a longitudinal transcriptomic atlas of maternal peripheral blood during healthy pregnancy, identifying 720 pregnancy-specific genes and nine transcriptional modules associated with immune and metabolic changes.

Genome-wide association study of placental weight in 179,025 children and parents reveals distinct and shared genetic influences between placental and fetal growth

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

Genetic effects on the timing of parturition and links to fetal birth weight

This study identifies genetic loci associated with gestational duration and preterm delivery, showing maternal and fetal genetic effects and antagonistic pleiotropy with birth weight.

An LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential for early cardiovascular disease intervention

The paper investigates the impact of the LDLR p.G137S variant on metabolic health and cardiovascular disease risk in Greenlanders, finding it increases FH and cardiovascular disease risk in up to 30% of the population.

Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci

This study identifies 81 genetic loci associated with different hernia types using genome-wide association analysis in the UK Biobank.

Mendelian randomization study of spermine oxidase and cancer risk

This study uses Mendelian randomization to test if SMOX levels causally affect cancer risk, finding no significant association with six cancer types.

Genome-wide association study of febrile seizures identifies seven new loci implicating fever response and neuronal excitability genes

This study identifies seven new genetic loci associated with febrile seizures, linking them to fever response and neuronal excitability genes, and suggests potential clinical applications of polygenic risk scores.

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

The paper identifies HLA-B*55:01 as a genetic risk factor for penicillin allergy through genome-wide analysis of electronic health records and imputed HLA data.

Ancestry-specific association mapping in admixed populations

This paper introduces a statistical method for association testing in admixed populations that allows ancestry-dependent effect sizes, improving power to detect associations and helping identify causal SNPs.

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

This study identifies a fetal genome-wide association signal near pro-inflammatory cytokine genes on 2q13 linked to gestational duration and preterm/postterm birth.

A Noninvasive Molecular Clock for Fetal Development Predicts Gestational Age and Preterm Delivery

This study uses cell-free RNA from blood samples to create a molecular clock for fetal development, predicting gestational age and preterm delivery risk.

Maternal and fetal genetic contribution to gestational weight gain

This study investigates the genetic contributions to gestational weight gain, finding that maternal common variants explain about 20% of variability, while fetal variants have a minor role.