Rachel Mester

Genetic and transcriptomic determinants of disseminated coccidioidomycosis identify a founder variant in NLRX1 and ancestry-specific rare variants in immune response genes

This study identifies genetic and transcriptomic factors associated with severe coccidioidomycosis, finding a founder variant in NLRX1 linked to African ancestry and increased disease risk.

Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations

Admix-kit provides tools for genetic analysis of admixed populations, enabling simulation, association testing, and polygenic scoring.

Impact of cross-ancestry genetic architecture on GWAS in admixed populations

This paper quantifies how differences in allelic effect sizes across ancestry backgrounds impact GWAS power in admixed populations and finds modeling these differences does not significantly improve results.

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals

The paper quantifies similarity in causal effects across local ancestries in admixed individuals and finds high genetic correlation (radmix=0.95) within individuals.

Differential Methods for Assessing Sensitivity in Biological Models

The paper compares differential sensitivity analysis methods for biological models, finding forward-mode differentiation is fastest and complex-perturbation is simplest to implement.