NeoCoMM: Neocortical Computational Microscale Model

Abstract

The Neocortical Computational Microscale model (NeoCoMM) is a unique neurophysiologically-inspired software. It offers a friendly graphical user interface that allows for the simulation of the intracellular and extracellular neural activity of a neocortical column. This software provides a realistic framework that can portray the neural activity and underlying cellular mechanisms related to different brain pathologies such as epilepsy. NeoCoMM is capable of (1) simulating the cortical tissue of three different species, (2) visualizing individual cell responses to external stimulation, (3) visualizing the corresponding local field potential, (4) studying the impact of the recording electrode features on simulated signals, and (5) testing various physiological and pathological hypotheses. While NeoCoMM was primarily developed for simulating epileptiform activity, it can also generate healthy brain rhythms or be adapted to other brain disorders.