bioRxivNeurosciencePreprint
An interactive 3D atlas of gene expression in the mouse brain
Harry CareyiD, Sébastien PilusoiD, Ingvild Elise BjerkeiD, Xiaoyun Gui, Sharon C. YatesiD, Sophia Pieschnik, Signý Benediktsdóttir, Archana GollaiD, Maja Amedjkouh PuchadesiD, Timo DickscheidiD, Trygve Brauns LeergaardiD, Simon McMullaniD, Henry MarkramiD, Daniel KelleriD, Jan Gunnar BjaalieiD
Abstract
The Allen Mouse Brain Atlas provides gene expression data for over 20,000 genes and has been extensively used in neuroscience. However, its constrained by a resolution of 200 {micro}m3. We improved this to 25 {micro}m3 for 4,083 genes by re-registering 401,660 sections to atlas space. From this, we produced an atlas with regions defined by shared molecular signatures and built an interactive online platform allowing exploration of gene expression patterns.
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