Konstantinos Meletis

The paper maps pallidostriatal connectivity in mice, showing distinct innervation patterns of striatal neuron subpopulations by different pallidal neuron types.

This study maps cell-type specific transcriptional changes in the parkinsonian striatum across species, identifying vulnerable and resilient cell types.

This study shows that Syngap1 in cortical neurons is essential for sensorimotor integration and perception by shaping neural dynamics and connectivity.

The paper identifies Anxa1+ dopamine neurons as vulnerable in prodromal Parkinson's disease, linking their dysfunction to bradykinesia and procedural motor learning impairments.

The paper identifies a striosomal ACB projection to the Esr1+ LHA-LHb pathway that drives compulsive seeking behaviors through aversive signaling.

The paper identifies striosomal pathways that target substantia nigra dopamine neurons, with opposite effects on movement compared to canonical pathways.

The paper shows that inhibitory PV interneurons in the rat medial prefrontal cortex encode spatial context during reward foraging.

The paper demonstrates that the mouse superior colliculus generates center-surround visual computations through local circuits, independent of top-down input.

This study identifies a selective subthalamostriatal projection to parvalbumin-expressing interneurons in the striatum, showing higher connectivity and excitatory responses compared to other cell types.

The paper identifies six glutamatergic neuron types in the LHA-LHb pathway, showing that Esr1+ neurons induce aversion and are involved in stress sensitivity in female mice.

The paper introduces SiT, a method to characterize spatial isoform variation and sequence heterogeneity in tissue sections, revealing regional isoform switching and RNA editing in mouse brain.

This study identifies Sst+ GPi neurons that provide feedback to basal ganglia nodes and influence behavioral flexibility during learning.

The paper assesses the replicability of spatial gene expression data from the adult mouse brain between two datasets, finding that classification performance is higher within datasets than across platforms.

The paper shows that all three major striatal output pathways represent action space and value similarly during motor and decision tasks.

This study shows that trkB signaling is critical for adult parvalbumin interneuron function and prefrontal network dynamics in mice.

The paper creates a molecular atlas of the adult mouse brain using spatial transcriptomics, revealing new subregions and a molecular code for spatial annotation.

The paper identifies the indusium griseum as a prenatal target of psychostimulants and shows that Scgn+/Vglut1+ neurons in this region are critical for neuronal excitability and linked to behavioral abnormalities.

The paper maps the molecular and spatial organization of striatal projection neurons, identifying new subtypes and spatial domains in both mice and non-human primates.