Lei Han

Single-cell spatial transcriptomics and snRNA-seq decoding the organizational principles of functional modules in the mouse amygdala

This study combines spatial transcriptomics and snRNA-seq to map cell type organization and functional modules in the mouse amygdala, revealing developmental origins and spatial patterns.

A Population-scale Single-cell Spatial Transcriptomic Atlas of the Human Cortex

This study creates a single-cell spatial transcriptomic atlas of the human cortex, revealing gene expression patterns, aging effects, and disease associations across layers and species.

Multimodal brain cell atlas across the adult macaque lifespan

The paper constructs a multimodal brain cell atlas of adult macaques across their lifespan, revealing aging-related molecular changes and identifying aging hotspots and regulatory loci.

Single-cell spatial transcriptome reveals pathological features of human hippocampus with sclerosis

This study uses single-cell spatial transcriptomics to identify molecular and cellular changes in hippocampal sclerosis associated with MTLE, revealing vulnerable subregions and novel pathological features.

Spatially resolved molecular and cellular atlas of the mouse brain

The paper creates a high-resolution spatial transcriptomic atlas of the mouse brain using snRNA-seq and Stereo-seq, identifying new cell clusters, region-specific genes, and transcription factor regulons.

Spatiotemporal transcriptome at single-cell resolution reveals key radial glial cell population in axolotl telencephalon development and regeneration

The paper uses Stereo-seq to map single-cell transcriptomes of axolotl telencephalon during development and regeneration, identifying a key radial glial cell subtype involved in early wound healing.

Spatially resolved gene regulatory and disease vulnerability map of the adult Macaque cortex

The paper integrates single-cell ATAC and transcriptomic data with spatial transcriptomics to map regulatory features and disease vulnerabilities in macaque cortex.