Expert-guided multi-objective optimization: an efficient strategy for parameter estimation of biological systems with limited data.
Léa Da Costa Fernandes, David Bernard, François Pérès, Paul Monsarrat, Béatrice Cousin, Sylvain Cussat‐Blanc
This paper introduces a hybrid calibration framework that integrates expert knowledge into multi-objective optimization for biological model parameter estimation, showing improved biological relevance and reduced overfitting.
Biosystems · Jan 2, 2026Peer-reviewedSystems Biology