David Bernard

This paper introduces a hybrid calibration framework that integrates expert knowledge into multi-objective optimization for biological model parameter estimation, showing improved biological relevance and reduced overfitting.

This study identifies how Oct4 differentially co-opts Bcl11a and Bcl11b to regulate reprogramming to pluripotency by revealing their opposing roles in cell fate conversion.

This paper develops a semi-automated image analysis framework to quantify spatiotemporal DNA damage foci in live tumor spheroids using live imaging and fluorescent sensors.

The paper shows that reduced DNA methylation in cancer cells leads to senescence without DNA damage, involving p21 and cGAS, and demonstrates this in vivo.

This study shows MYC regulates ITPR1 to control ER-mitochondria calcium transfer, inducing cell death in normal cells but exploited by cancer cells for survival.

The paper shows 5-FU induces translational reprogramming in colorectal cancer cells, enhancing drug tolerance through pro-tumoral gene expression and IL-8 overexpression.

The paper introduces a methodology and web platform called ISiCell to improve collaboration between biologists and modelers in creating agent-based models for cell biology.