Human and Mouse Models of the Bipolar Disorder-Associated ANK3 p.W1989R Variant Display Altered Somatostatin Interneuron Connectivity and Function
Kendall P. Dean, Sarah C. Verduci, Clayton C. Kramm, Cooper Stinson, Lia Y. Min, Jennifer S. Smith, Cynthia J. DeLong, Mingjia Yao, Kun H. Lee, J. Reeves, William T. Birdsong, Joshua D. Welch, Paul M. Jenkins
This study investigates the effects of the ANK3 p.W1989R variant in human and mouse models, showing altered somatostatin interneuron connectivity and function linked to bipolar disorder.
bioRxiv · Oct 23, 2026 · PreprintNeuroscience