Paul M. Jenkins

This study investigates the effects of the ANK3 p.W1989R variant in human and mouse models, showing altered somatostatin interneuron connectivity and function linked to bipolar disorder.

The paper identifies a neuron type-specific microexon in Ank3/ankyrin-G that modulates calcium activity and neuronal excitability through alternative splicing.

This study shows that CRISPR activation can rescue electrophysiological deficits in SCN2A haploinsufficiency by increasing the expression of the remaining functional allele in mice and human neurons.

This paper introduces a novel mouse reporter line for live imaging of axon initial segments, enabling real-time study of AIS plasticity in vivo.

This study shows that Ank2 and Scn2a work together in dendrites of neocortical neurons, linking their dysfunction to autism spectrum disorder.

This study shows that inhibitory synaptic transmission is impaired in male, but not female, Rett Syndrome mice in the Kölliker-Fuse region, suggesting sex-dependent mechanisms in breathing abnormalities.

The paper develops a method to study gamma-band coherence in ex vivo hippocampal slices from a mouse model of bipolar disorder, finding increased coherence despite reduced gamma power.

This study shows that Dscam overexpression in Down syndrome mouse models causes excessive GABAergic inhibition of neocortical pyramidal neurons.

This study identifies S-palmitoylation of ankyrin-B as critical for its dendritic localization and function in scaffolding Nav1.2, while axonal functions remain unaffected.

This study identifies synaptotagmin-7 as a Ca2+ sensor in splanchnic nerve terminals that regulates acetylcholine release and short-term presynaptic facilitation.

This study shows that ankyrin-G regulates forebrain connectivity and network synchronization through its interaction with GABARAP, and identifies a variant linked to bipolar disorder.