Chronic Myeloid Leukemia Treatments

Leukemic fitness predicts treatment-free remission and guides adaptive therapy in chronic myeloid leukemia

This paper develops a minimal mathematical model to predict treatment-free remission in chronic myeloid leukemia using leukemic fitness, and proposes adaptive therapy strategies based on this parameter.

AMPK Signalling Rewires WWP1 mediated RUNX1 Ubiquitination in CML Progression

This study identifies WWP1 as a regulator of RUNX1 ubiquitination in CML, showing that AMPK modulates WWP1 and RUNX1 phosphorylation to influence leukemic progression.